Descrizione

✅ What is Semaglutide?

Semaglutide is a GLP-1 receptor agonist, originally developed for the treatment of type 2 diabetes, and now widely used for weight loss in people with obesity or overweight—even without diabetes. It works by mimicking the GLP-1 hormone, which helps regulate blood sugar levels, reduce appetite, and promote satiety.

🌡️ Main Benefits of the 5 mg Dose

1. Improved Blood Sugar Control

• Helps lower HbA1c levels significantly.
• Reduces blood glucose spikes after meals.
• Supports better glycemic control in people with type 2 diabetes.

2. Effective Weight Loss

• Promotes a steady and sustained reduction in body weight, even at lower doses like 5 mg.
• Works by:
  • Suppressing appetite
  • Slowing gastric emptying
  • Enhancing the feeling of fullness

3. Cardiovascular Benefits

• Clinical trials have shown that Semaglutide can reduce the risk of major cardiovascular events such as heart attack and stroke in patients with type 2 diabetes.

4. Metabolic Health Support

• May help improve cholesterol and triglyceride levels.
• Supports insulin sensitivity.
• Reduces inflammation and oxidative stress markers.

🧪 Clinical Trial Highlights

In large-scale clinical studies like SUSTAIN and STEP, Semaglutide has shown to:

• Lower HbA1c by up to 1.8%
• Promote weight loss of 5–15% of initial body weight (depending on dose and duration)
• Improve quality of life and eating behavior

⚠️ Common Side Effects

• Nausea (especially at the beginning)
• Vomiting
• Diarrhea or constipation
• Fatigue or dizziness

These are usually mild to moderate and decrease over time as the body adapts.

💉 Dosing & Use

• 5 mg is typically used during dose escalation or as a maintenance dose depending on patient needs and tolerance.
• Administered once weekly via subcutaneous injection.

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